Just to flesh out the topic of using an SSD with the Raspberry Pi3B, there is one critical problem area. The on-board Wi-Fi.
The problems between the on-board Wi-Fi and Bluetooth are well documented with the only solution to using both being to disable the on-board Bluetooth and use a hub version
There is however an additional issue between the Wifi and the SSD which causes frequent Wifi drop-outs. The Pi3B Wifi is bad at the best of times but SSD+Wi-Fi are just about unworkable. By observation the Wi-Fi drops out as soon as the SSD starts to file manage so it is either i/o or power. I have not found a solution, and in my current construction cannot use a powered hub to test if SSD power drain is the issue. Instead I’m going to use a Homeplug+Ethernet solution.